Gum Acacia-cl-poly(acrylamide)@carbon nitride Nanocomposite Hydrogel for Adsorption of Ciprofloxacin and its Sustained Release in Artificial Ocular Solution

In the present work, a nanocomposite hydrogel is designed consisting of gum acacia, poly(acrylamide) and carbon nitride by facile microwave approach. This nanocomposite hydrogel is sensitive to environmental stimuli which is essential for its application in environmental remediation and as a drug delivery system. The effects of carbon nitride percentage and microwave Watt variation on swelling capacity of gum acacia-cl-poly(acrylamide)@carbon nitride (Ga-cl-PAM@C3N4) nanocomposite hydrogel are analyzed. The structural characterizations are considered by numerous techniques such as FTIR (Fourier transform infra-red spectroscopy), X-ray diffraction, transmission electron microscopy, scanning electron microscopy, and elemental mapping. Batch experiment is performed for remediation of ciprofloxacin (CIP) drug from water. Various parameters such as effect of ciprofloxacin doses, Ga-cl-PAM@C(3)N(4)nanocomposite hydrogel dosage, pH, time and temperature for adsorption of CIP on gum acacia-cl-poly(acrylamide)@carbon nitride nanocomposite hydrogel is examined. Maximum adsorption capacity of Ga-cl-PAM@C(3)N(4)nanocomposite hydrogel observed is 169.49 mg g(-1)at pH 6.4. The drug loading and drug release capacity of Ga-cl-PAM@C(3)N(4)nanocomposite hydrogel is investigated for ciprofloxacin. Drug release is monitored in artificial ocular solution (pH 8), saline (pH 5.5), acetate buffer (pH 2.2), and distilled water. Maximum drug release is observed in artificial ocular solution.