期刊
LIVER INTERNATIONAL
卷 40, 期 9, 页码 2160-2163出版社
WILEY
DOI: 10.1111/liv.14575
关键词
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资金
- National Natural Science Foundation of China [81500665]
- Ruian Science and Technology Bureau [2020023]
- High Level Creative Talents from Department of Public Health in Zhejiang Province
- Project of New Century 551 Talent Nurturing in Wenzhou
The Corona Virus Disease 2019 (COVID-19) pandemic has attracted increasing worldwide attention. While metabolic-associated fatty liver disease (MAFLD) affects a quarter of world population, its impact on COVID-19 severity has not been characterized. We identified 55 MAFLD patients with COVID-19, who were 1:1 matched by age, sex and obesity status to non-aged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients without MAFLD. Our results demonstrate that in patients aged less than 60 years with COVID-19, MAFLD is associated with an approximately fourfold increase (adjusted odds ratio 4.07, 95% confidence interval 1.20-13.79,P = .02) in the probability for severe disease, after adjusting for confounders. Healthcare professionals caring for patients with COVID-19 need to be aware that there is a positive association between MAFLD and severe illness with COVID-19.
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