期刊
LIPIDS IN HEALTH AND DISEASE
卷 19, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12944-020-01307-6
关键词
Diabetic nephropathy; Type 2 diabetes; Apolipoprotein E; Polymorphism; Risk; Association
资金
- National Natural Science Foundation of China [81573230]
- Organizational Management Model and Construction of Evaluation Index System for Comprehensive Demonstration Base of Prevention and Control Technology of Major Chronic Disease in Northeast China [2018YFC1311600]
Background Diabetic nephropathy (DN) contributes to end-stage renal failure. Microvascular injury resulted from reactive oxygen species is implicated in the pathogenesis of DN. Genetic polymorphism of Apolipoprotein E (APOE) influences the antioxidative properties of the protein. The relationship ofAPOEpolymorphism with the risks of nephropathy in type 2 diabetes (T2DN) remains elusive. Methods An up-to-date meta-analysis was conducted on the basis of studies selected from PubMed, WanFang database, Embase, Vip database, Web of Science, Scopus, and CNKI database. Results A total of 33 studies conferring 3266 cases and 3259 controls were selected on the basis of criteria of inclusion and exclusion in this meta-analysis. ForAPOEalleles, the pooled odds ratio (OR) of epsilon 2 vs. epsilon 3 was 1.89 (95% confidence intervals [95% CI]: 1.49-2.38,P < 0.0001). With regard toAPOEgenotypes, epsilon 2/epsilon 2, epsilon 2/epsilon 3, and epsilon 2/epsilon 4 increased the risk of T2DN (epsilon 2/epsilon 2 vs. epsilon 3/epsilon 3: OR = 2.32, 95% CI: 1.52-3.56,P = 0.0001; epsilon 2/epsilon 3 vs. epsilon 3/epsilon 3: OR = 1.97, 95% CI: 1.50-2.59,P<0.0001; epsilon 2/epsilon 4 vs. epsilon 3/epsilon 3: OR = 1.69, 95% CI: 1.18-2.44,P = 0.0046). Conclusions This meta-analysis found that theAPOE epsilon 2 allele and the epsilon 2-involved genotypes (epsilon 2/epsilon 2, epsilon 2/epsilon 3, and epsilon 2/epsilon 4) are the risk factors of T2DN.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据