期刊
KIDNEY INTERNATIONAL
卷 98, 期 1, 页码 51-53出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.kint.2020.03.021
关键词
-
资金
- National Institutes of Health [K23DK120811]
- Dixon Translational Research Grants Initiative at Northwestern Medicine
- Northwestern University Clinical and Translational Sciences Institute [UL1TR001422]
- George M. O'Brien Kidney Research Center at Northwestern University (NU-GoKIDNEY) [P30DK114857]
- [R01DK106557]
Mitochondrial dysfunction is thought to be a critical pathway in the development and progression of kidney diseases, but optimal methods to assess kidney mitochondrial dysfunction are not well known. Saeki and colleagues use positron emission tomography imaging with a novel probe, 2-tert-butyl-4-chloro-5-[6-(4-F-18-fluorobutoxy)-pyridin-3-ylmethoxy]-2H-pyridazin-3-one (F-18-BCPP-BF), to visualize and assess kidney mitochondrial status. The authors demonstrate that reduced uptake of 18F-BCPP-BF, as assessed by positron emission tomography imaging, corresponds to reduced functioning mitochondria in 3 separate animal models of kidney diseases. Copyright (C) 2020, International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据