期刊
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
卷 21, 期 8, 页码 603-610出版社
ZHEJIANG UNIV
DOI: 10.1631/jzus.B2000022
关键词
Thoracic aortic dissection (TAD); beta-Aminopropionitrile (BAPN); Angiotensin II (AngII); Mouse model; Hypertension; R543; 1
Thoracic aortic dissection (TAD) is one of the most lethal aortic diseases due to its acute onset, rapid progress, and high rate of aortic rupture. The pathogenesis of TAD is not completely understood. In this mini-review, we introduce three emerging experimental mouse TAD models using beta-aminopropionitrile (BAPN) alone, BAPN for a prolonged duration (four weeks) and then with added infusion of angiotensin II (AngII), or co-administration of BAPN and AngII chronically. We aim to provide insights into appropriate application of these three mouse models, thereby enhancing the understanding of the molecular mechanisms of TAD.
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