期刊
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
卷 51, 期 3, 页码 682-692出版社
SPRINGER
DOI: 10.1007/s11239-020-02184-7
关键词
Stent thrombosis; Outcomes; Percutaneous coronary intervention; Meta-analysis
资金
- National 135 Key Research and Development Program in 2016 [2016YFC1301203]
- Major Science and Technology Projects of Tianjin Science and Technology Commission in 2016 [16ZXMJSY00150]
- Key Project of Healthcare Industry of Tianjin in 2016 [16KG131]
- Science and Technology Project of Tianjin Jin nan District Science and Technology Commission [20171514]
The study found that patients with early stent thrombosis (EST) had significantly higher mortality rates and target vessel revascularization compared to those with late stent thrombosis (LST/VLST) in both short- and long-term follow-up after percutaneous coronary intervention (PCI). Further research is needed to determine optimal treatment strategies for EST.
Whether the clinical outcomes of stent thrombosis (ST) are different when stratified by time of occurrence remains unclear. The objective of this study was to compare the short- and long-term clinical outcomes after percutaneous coronary intervention (PCI) for early stent thrombosis (EST) versus late stent thrombosis (LST) and very late stent thrombosis (VLST). We enrolled eligible studies searched from the main electronic databases (EMBASE, PubMed, Cochrane). The primary endpoints were in-hospital, 30-day, 1-year and long-term mortality. The secondary endpoints included recurrent stent thrombosis (RST) and target vessel/lesion revascularization (TVR/TLR) during hospitalization, at 30 days, at 1 year and at long-term follow-up. A total of 23 studies with 17,592 patients were included. Compared with mortality rates of the late and very late thrombosis (LST/VLST) group, in-hospital (P = 0.004), 30-day (P < 0.00001), 1-year (P < 0.00001) and long-term mortality rates (P = 0.04) were significantly higher in the EST group. The in-hospital TVR/TLR rates were similar between the EST group and the LST/VLST group. However, a higher trend in TVR/TLR rate at 30 days and a significantly higher TVR/TLR rate at 1 year (P = 0.002) as well as at long-term follow up (P = 0.009) were found in the EST group. EST patients also trended toward higher risk of RST in both short- and long-term follow-up than LST/VLST patients, although differences were not statistically significant. After PCI treatment, patients with EST have worse clinical outcomes in both short- and long-term follow-up than patients with LST/VLST. Further studies are warranted to determine the optimal treatment strategies for EST.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据