期刊
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
卷 100, 期 15, 页码 5442-5449出版社
WILEY
DOI: 10.1002/jsfa.10595
关键词
fructooligosaccharides; prebiotics; inflammation; intestinal barrier; oxidative stress
资金
- Fundacao de Amparo a Pesquisa e Inovacao do Espirito Santo (FAPES) [0593/2015]
- Coordenacao de Aperfeicoamento de Pessoa de Nivel Superior (CAPES) [001]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq
BACKGROUND Yacon (Smallanthus sonchifolius) roots store carbohydrate in the form of prebiotic fructooligosaccharides (FOS), which improve intestinal health. Yacon has the potential to prevent the intestinal barrier alterations associated with colorectal cancer (CRC). This study aimed to investigate the preventive effects of yacon flour (YF) on alterations promoted by CRC induced by 1,2-dimethylhydrazine in rats. RESULTS CRC increased tumor necrosis factor alpha levels (group CY = 10.2 +/- 0.72; group C = 9.6 +/- 1.0; group Y = 5.8 +/- 0.54; group S = 5.95 +/- 0.6 pg mL(-1)) and short-chain fatty acid production, and decreased total antioxidant capacity (group CY = 4.7 +/- 0.72; group C = 3.3 +/- 0.3; group Y = 4.1 +/- 0.47; group S = 6.7 +/- 0.78 U mL(-1)). Furthermore, YF treatment reduced intraluminal pH (group CY = 6.45 +/- 0.47; group C = 7.65 +/- 0.44; group Y = 6.75 +/- 0.46; group S = 8.13 +/- 0.2), lactulose/mannitol ratio, tumor necrosis factor-alpha (TNF-alpha)/interleukin (IL)-10 ratio, and increased secretory immunoglobulin A (group CY = 9.48 +/- 1.46; group C = 10.95 +/- 3.87; group Y = 15.95 +/- 7.36; group S = 9.19 +/- 1.52), but did not affect IL-10, IL-12, and TNF-alpha levels nor the IL-12/IL-10 ratio. CONCLUSION YF as a source of fructooligosaccharides may help to maintain the integrity of intestinal health, which is altered in induced CRC in rats. (c) 2020 Society of Chemical Industry
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