期刊
JOURNAL OF THE ROYAL SOCIETY INTERFACE
卷 17, 期 167, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsif.2020.0177
关键词
bioelectricity; osmotic stress; electrostatic stress; mechanical stress; mechanosensitive ion channels; morphogenesis
资金
- Italian Ministry of Education, University and Research (MIUR)
- Royal Academy of Engineering, London, UK
- Paul G. Allen Frontiers Group [12171]
The role of endogenous bioelectricity in morphogenesis has recently been explored through the finite volume-based code BioElectric Tissue Simulation Engine. We extend this platform to electrostatic and osmotic forces due to bioelectrical ion fluxes, causing cell cluster deformation. We further account for mechanosensitive ion channels, which, gated by membrane tension, modulate ion fluxes and, ultimately, bioelectrical forces. We illustrate the potentialities of this combined model of actuation and sensing with reference to cancer progression, osmoregulation, symmetry breaking and long-range signalling. This suggests control strategies for the manipulation of cell networks in vivo.
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