期刊
CLINICAL INFECTIOUS DISEASES
卷 62, 期 10, 页码 1272-1276出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciw123
关键词
Ebola virus disease; sexually transmitted infection; viral shedding in semen and vaginal fluid; viral compartmentalization; emerging infectious diseases
资金
- NCATS NIH HHS [UL1 TR001111, KL2 TR001109] Funding Source: Medline
- NIAID NIH HHS [K23 AI121516] Funding Source: Medline
- NIA NIH HHS [R03 AG045088] Funding Source: Medline
- NIDA NIH HHS [K24 DA037101] Funding Source: Medline
The unprecedented Ebola outbreak that devastated West Africa evolved within months from a regional outbreak to a global public health emergency. While the rate of confirmed cases declined dramatically, sporadic clusters of Ebola virus disease (EVD) continue well beyond the double incubation period of 42 days used to declare a nation Ebola-free. At the same time, evidence that the virus persists in genital fluids and can be sexually transmitted, along with the potential for lingering virus in other body compartments to permit recrudescence of EVD, has shaken our thinking of what it takes to achieve lasting control of an Ebola epidemic. A comprehensive response to the threat of persistence and sexual transmission of Ebola is required and should build on accessible longitudinal medical care of survivors and accurate genital fluid testing for Ebola. Control of this and future Ebola outbreaks will depend on our ability to recognize and respond to this persistence of the virus in those who survive.
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