期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 142, 期 26, 页码 11370-11375出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.0c04499
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资金
- Institute for Basic Science [IBS-R010-A2]
- National Research Foundation of Korea [21A20151513223] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Reported herein is a general strategy for the photochemical cross-coupling between N-amidopyridinium salts and various alkyl bromides under photocatalyst-free conditions, granting facile access to various C4-alkylated pyridines. This approach exploits the intriguing photochemical activity of electron donor-acceptor (EDA) complexes between N-amidopyridinium salts and bromide, which provides a photoactive handle capable of generating silyl radicals and driving the alkylation process. The robustness of this protocol was further demonstrated by the late-stage functionalization of complex compounds under mild and metal-free conditions.
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