期刊
JOURNAL OF SURGICAL ONCOLOGY
卷 122, 期 5, 页码 914-922出版社
WILEY
DOI: 10.1002/jso.26101
关键词
accuracy; esophageal adenocarcinoma; staging
Background Given the survival advantage of neoadjuvant treatment for locally advanced esophageal cancer, accurate clinical staging is necessary. The aim of this study was to assess the clinical (c) and pathologic (p) staging concordance rates for presumably early stage esophageal adenocarcinoma patients that had upfront esophagectomy (UFE) and evaluate if survival (OS) was negatively affected by inaccurate preoperative staging and subsequent treatment selection. Methods An NCDB retrospective review of nonmetastatic esophageal adenocarcinoma patients that had UFE. The rates of concordance between c and p staging system and OS were calculated. Results Of 2775 patients, most patients presented with cN0 (82.8%) and cT1 tumors (53.6%). The overall concordance between c and p staging was 78.8% for T-classification (moderate agreement; weighted kappa = 0.729;P < .001) and 78.8% for N-classification (weak agreement; weighted kappa = 0.448;P < .001). Patients that were upstaged due to a lack of concordance between T-classification had decreased 5- and 10-year OS (30% and 16%,P < .001) and those upstaged due to discordant N-classification had decreased 5- and 10-year OS (28% and 23%,P < .001). Conclusions Preoperative staging of esophageal adenocarcinoma has moderate reliability and accuracy for predicting pT and pN classification. Up to 25% of patients have discordant clinical and pathological staging, which impacts OS.
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