期刊
JOURNAL OF PSYCHIATRIC RESEARCH
卷 127, 期 -, 页码 57-61出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2020.05.016
关键词
Treatment resistant schizophrenia; Deep brain stimulation; Positron emission tomography
类别
资金
- FEDER funds of the EU
- ONA CORPORATION [IIBSP-AMA-2016-99]
- CERCA Programme/Generalitat de Catalunya
Deep brain stimulation (DBS) has been found to be effective in treatment resistant neurological and psychiatric disorders. So far there has been only one completed trial in schizophrenia, in which seven treatment resistant patients received DBS in the subgenual anterior cingulate cortex (sgACC, N = 4) or the nucleus accumbens (NAc, N = 3); four ma symptomatic response criteria over the trial period. Six patients underwent 18 F-FDG PET at baseline and after a least 6 months of stimulation. Individual patient analysis indicated that DBS to both the sgACC and NAc was associated with local and distant changes in glucose metabolism. Increments and decrements of brain activity were observed in regions that included the medial prefrontal cortex, the dorsolateral prefrontal cortex, the anterior cingulate cortex, the caudate nucleus, the NAc, the hippocampus and the thalamus. Increased activity appeared to be associated with clinical improvement. These preliminary findings suggest that DBS acts by modulating cerebral activity in the cortico-basal-thalamic-cortical circuit in patients with schizophrenia who show improvement in psychotic symptoms.
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