4.7 Article

Comparative effect of 25(OH)D3 and 1,25(OH)2D3 on Th17 cell differentiation

期刊

CLINICAL IMMUNOLOGY
卷 166, 期 -, 页码 59-71

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2016.02.011

关键词

Th17; Vitamin D; IL-17A

资金

  1. National Council for Scientific Research (CNRS) [020812]
  2. Medical Practice Plan/University Research Board (MPP/URB)

向作者/读者索取更多资源

Vitamin D is a secosteroid hormone that plays an important regulatory role in calcium homeostasis and bone metabolism. Immune cells can both produce and respond to 1,25(OH)(2)D3. CD4+ T cells from vitamin D receptor (VDR) KO mice produce higher levels of IFN-gamma and IL-17 than their wild type counterparts, and play a crucial role in the pathogenesis of autoimmune diseases (AID). We are particularly interested in studying the effect of vitamin D on pathogenic Th17 cells in humans. We investigated the in vitro effect of 1,25(OH)(2)D3 and 25(OH)D3 on the differentiation and cytokine production of primary CD4+ T cells from normal donors, and cultured in Th17 polarizing conditions. Both forms of vitamin D reduced the expression of pathogenic Th17 markers and their secretion of pro-inflammatory cytokines (IL-17A, IFN-gamma). Furthermore, both vitamin D forms induced an expansion of CD25hi cells and upregulated their expression of CTLA-4 and Foxp3 regulatory markers. (C) 2016 Elsevier Inc. All rights reserved.

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