期刊
CLINICAL IMMUNOLOGY
卷 173, 期 -, 页码 161-170出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2016.10.017
关键词
Bcl-6; cTfh; SLE; Disease activity; IL-21; TET2
类别
资金
- National Natural Science Foundation of China [81210308042, 81430074, 81220108017, 81602767, 30972745]
- Fundamental Research Funds for the Central Universities of Central South University [2016zzts133]
Increased circulating follicular helper-like T cells (cTfh) are reported in systemic lupus erythematosus (SLE) patients. However, whether B-cell lymphoma 6 (Bcl-6) is expressed in cTfh cells remains to be clarified. In this study, we found that the frequencies of CD4(+)CXCR5(hi)PD-1(hi)cTfh, CD4(+)CXCR5(hi)PD-1(hi)lCOS(hi), and CD4(+)CXCR5(hi)PD-1(hi)Bcl-6(+) populations were significantly increased in SLE patients (n = 70) when compared with healthy controls (n = 48). Surprisingly, only CD4(+) CXCR5(hi)PD-1(hi)Bcl-6(+) cTfh cells, rather than CD4(+)CXCR5(hi)PD-1(hi) population, were positively correlated with SLEDAI and anti-dsDNA antibodies. An elevated level of IL-21 was found in SLE CD4(+) T cells. Moreover, IL-21 promoted the enrichment of TET2 in Bcl-6 promoter region and induced Bcl-6 expression. Therefore, Bcl-6 expression in cTfh cells may represent a reliable marker for the disease activity in SLE. (C) 2016 Elsevier Inc All rights reserved.
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