4.6 Article

Steady-state fluctuations of a genetic feedback loop with fluctuating rate parameters using the unified colored noise approximation

出版社

IOP PUBLISHING LTD
DOI: 10.1088/1751-8121/aba4d0

关键词

Fokker-Planck equation; gene regulatory networks; stochastic gene expression; stochastic simulations

资金

  1. BBSRC EASTBIO PhD studentship
  2. Darwin Trust scholarship
  3. Leverhulme Trust [RPG-2018-423]

向作者/读者索取更多资源

A common model of stochastic auto-regulatory gene expression describes promoter switching via cooperative protein binding, effective protein production in the active state and dilution of proteins. Here we consider an extension of this model whereby colored noise with a short correlation time is added to the reaction rate parameters-we show that when the size and timescale of the noise is appropriately chosen it accounts for fast reactions that are not explicitly modeled, e.g., in models with no mRNA description, fluctuations in the protein production rate can account for rapid multiple stages of nuclear mRNA processing which precede translation in eukaryotes. We show how the unified colored noise approximation can be used to derive expressions for the protein number distribution that is in good agreement with stochastic simulations. We find that even when the noise in the rate parameters is small, the protein distributions predicted by our model can be significantly different than models assuming constant reaction rates.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据