期刊
CLINICAL IMMUNOLOGY
卷 173, 期 -, 页码 157-160出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2016.10.015
关键词
Sjogren's Syndrome; Type I Interferon; Autoimmunity; Gene polymorphisms; PTPN22
类别
资金
- S. Niarchos Foundation
- Hellenic Rheumatology Society
Recent data suggest the association of the autoimmune gene variant PTPN22W* with dampened type I Interferon (IFN) responses, seen in a subset of primary Sjogren's Syndrome (pSS) patients. We sought to explore the potential contribution of PTPN22W* in this setting. PTPN22W* was identified in DNA samples derived from 352 pSS patients and 482 healthy controls (HC). Type I IFN score was determined in available peripheral blood cDNA of 164 pSS patients by Real-Time PCR. Increased prevalence of the PTPN22W* variant was detected in pSS patients compared to HC [9.7% vs 5.0%, p-value: 0.02]. Of interest, only the low but not the high type I IFN pSS subgroup displayed higher PTPN22W* rates compared to HC (12.2% vs 5.0%, p-value: 0.03). PTPN22W* risk variant increases susceptibility for pSS, particularly the low typeI IFN subset implying the presence of distinct genetic backgrounds among low and high type I IFN autoimmune subgroups. (C) 2016 Elsevier Inc. All rights reserved.
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