期刊
CLINICAL IMMUNOLOGY
卷 168, 期 -, 页码 25-29出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2016.04.002
关键词
Sjogren's syndrome; X chromosome; Klinefelter's syndrome; Sex bias
类别
资金
- NIH [AR053483, AI082714, AR053734, GM104938]
- US Department of Veterans Affairs
- MRC [G0800629] Funding Source: UKRI
- Medical Research Council [G0800629] Funding Source: researchfish
Primary Sjogren's syndrome (pSS) has a strong female bias. We evaluated an X chromosome dose effect by analyzing 47,XXY (Klinefelter's syndrome, 1 in 500 live male births) among subjects with pSS. 47,XXY was determined by examination of fluorescence intensity of single nucleotide polymorphisms from the X and Y chromosomes. Among 136 pSS men there were 4 with 47,XXY. This was significantly different from healthy controls (1 of 1254 had 47)0(Y, p = 0.0012 by Fisher's exact test) as well men with rheumatoid arthritis (0 of 363 with 47,XXY), but not different compared to men with systemic lupus erythematosus (SLE) (4 of 136 versus 8 of 306, Fisher's exact test p = NS). These results are consistent with the hypothesis that the number of X chromosomes is critical for the female bias of pSS, a property that may be shared with SLE but not RA. Published by Elsevier Inc.
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