期刊
JOURNAL OF PHARMACOLOGICAL SCIENCES
卷 144, 期 3, 页码 183-187出版社
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1016/j.jphs.2020.07.012
关键词
5-Aminolevulinic acid; Neuroprotection; Oxidative stress
资金
- Smoking Research Foundation
- JSPS KAKENHI
- MEXT, Japan [16H07341, 18K06904, 18K15034]
- Grants-in-Aid for Scientific Research [18K15034, 16H07341, 18K06904] Funding Source: KAKEN
Oxidative stress is associated with the progression of the neurodegenerative diseases Parkinson's disease (PD) and cerebral ischemia. Recently, 5-aminolevulinic acid (5-ALA), an intermediate in the porphyrin synthesis pathway, was reported to exert antioxidative effects on macrophages and cardiomyocytes. Here, we demonstrated the neuroprotective effects of 5-ALA using rat models of PD and ischemia as well as in vitro in SH-SY5Y cells. 5-ALA partially prevented neurodegeneration in each condition. These results suggest that 5-ALA has a potential for promising therapeutic agent to protect against neurodegeneration exacerbated by oxidative stress. (C) 2020 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.
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