期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 85, 期 16, 页码 10872-10883出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.0c01433
关键词
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资金
- National Key Research and Development Program of China [2019YFA0905100]
- National Natural Science Foundation of China [21532008, 21772142, 21901181, 21971186]
- Tianjin University
The general synthesis of fully substituted N-2-aryl-1,2,3-triazoles is hitherto challenging compared with that of the N-2-aryl counterparts. Herein, we describe a Cu-catalyzed annulation reaction of azirines and aryldiazonium salts. This regiospecific method allows access to a broad spectrum of tri-carbo N-2-aryl-1,2,3-triazoles substituted with diverse aryl and alkyl moieties. Its utility is highlighted by the synthesis of several triazole precursors applicable in drug discovery, as well as novel chiral binaphthyl ligands bearing triazole moieties.
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