期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 85, 期 16, 页码 10994-11005出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.0c01291
关键词
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资金
- National Research Foundation of Korea [NRF-2017R1A2A2A05069364, NRF-2018R1A6A1A03023718, NRF-2019R1I1A1A01061117, NRF-2020R1A2C2005961]
- Yonsei University Research Fund [2019-12-0013]
A highly efficient synthetic route to new quinone-indolizine hybrids was accomplished from quinones and N-substituted pyrrole-2-carboxaldehydes via a domino Michael addition-aldol condensation-aromatization sequence through which the central pyridine ring was constructed in atom-economical and environment-friendly manner. Post modification of the resulting products was also demonstrated, enabling further expansion of this heterocyclic chemical space. Biological evaluation of the quinone-indolizine hybrids revealed potent anticancer effects in human prostate adenocarcinoma cells (PC-3) and oral adenosquamous carcinoma cells (CAL-27).
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