期刊
JOURNAL OF NEUROSCIENCE RESEARCH
卷 98, 期 11, 页码 2275-2289出版社
WILEY
DOI: 10.1002/jnr.24709
关键词
PPAR; stroke; MCAO; therapy
资金
- American Heart Association [18POST34030195/Marcin Gamdzyk/2018]
- National Institute of Health [NS104083]
Role of peroxisome proliferator-activated receptors (PPARs) in the pathophysiology of stroke and protective effects of PPAR ligands have been widely investigated in the last 20 years. Activation of all three PPAR isoforms, but especially PPAR-gamma, was documented to limit postischemic injury in the numerousin vivo, as well as inin vitrostudies. PPARs have been demonstrated to act on multiple mechanisms and were shown to activate multiple protective pathways related to inflammation, apoptosis, BBB protection, neurogenesis, and oxidative stress. The aim of this review was to summarize two decades of PPAR research in stroke with emphasis onin vivoanimal studies. We focus on each PPAR receptor separately and detail their implication in stroke. This review also discusses recent clinical efforts in the field and the epidemiological data with regard to role of PPAR polymorphisms in susceptibility to stroke, and tries to draw conclusions and describe future perspectives.
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