期刊
JOURNAL OF NATURAL PRODUCTS
卷 83, 期 8, 页码 2313-2319出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00925
关键词
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资金
- National Natural Science Foundation of China [U1801287, 81630095, 81803377]
- National Key Research and Development Program of China [2017YFC1703802]
- Science and Technology Planning Project of Guangdong Province [2018B020207008]
- Natural Science Foundation of Guangdong Province [2018A030310640]
- Local Innovative and Research Teams Project of Guangdong PRT Program [2017BT01Y036]
- High Performance Supercomputing Platform of Jinan University
Six new structurally diverse indole alkaloids, melohemsines J-M (1-4), 11-hydroxy-Delta(14)-vincamine (5), and 11-hydroxy-16-epi-Delta(14)-vincamine (6), and 15 known alkaloids were isolated from the leaves and twigs of Melodinus hemsleyanus Diels. These new compounds and their absolute configurations were determined through spectroscopic data analyses, X-ray diffraction, and computational methods. Melohemsine J (1) is the first example of a melodinus-type alkaloid possessing a 6/6/5/5/6/5 hexacyclic skeleton and containing a tetrahydrofuro[2,3-b]pyridine2(3H)-one unit. Melohemsine K (2) is an unusual aspidosperma-type alkaloid possessing a 6/5/6/5/5 pentacyclic architecture with a contracted E ring (loss of CH2). Compounds 5-10 and 16 exhibited vasorelaxant activities with EC50 values of 0.8-3.8 mu M. In addition, compound 4 displayed moderate cytotoxicity toward the tumor cell lines HepG2 and A-549 with EC50 values of 18.7 and 28.7 mu M, respectively.
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