期刊
JOURNAL OF MOLECULAR LIQUIDS
卷 312, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.molliq.2020.113249
关键词
Budesonide; Hydrocortisone; Prednisolone; (Ethanol plus water) mixtures; Solubility; Preferential solvation
资金
- Tabriz University of Medical Sciences, Tabriz, Iran [62733]
The equilibrium solubility of three corticosteroids, namely, budesonide, hydrocortisone and prednisolone in some {ethanol (1) + water (2)} mixtures as expressed in mole fraction at 298.2 K was calculated from reported solubility values expressed in molarity scale. Further, by using the inverse Kirkwood-Buff integrals is observed that these drugs are preferentially solvated by water molecules in water-rich mixtures and apparently also in ethanol-rich mixtures but preferentially solvated by ethanol molecules in mixtures of similar proportions of the solvents. (C) 2020 Elsevier B.V. All rights reserved.
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