Preferential solvation of some corticosteroids in {ethanol (1) + water (2)} mixtures at 298.2 K

The equilibrium solubility of three corticosteroids, namely, budesonide, hydrocortisone and prednisolone in some {ethanol (1) + water (2)} mixtures as expressed in mole fraction at 298.2 K was calculated from reported solubility values expressed in molarity scale. Further, by using the inverse Kirkwood-Buff integrals is observed that these drugs are preferentially solvated by water molecules in water-rich mixtures and apparently also in ethanol-rich mixtures but preferentially solvated by ethanol molecules in mixtures of similar proportions of the solvents. (C) 2020 Elsevier B.V. All rights reserved.