期刊
JOURNAL OF MOLECULAR LIQUIDS
卷 317, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.molliq.2020.113906
关键词
Curcumin; Ionic liquids; Solubilization; Micelle; Surfactant
The limited water solubility of curcumin becomes an obstacle in its preparation, processing, and application. Ionic liquids (ILs) were wildly applied as green solvents possessing design flexibility. Three types of ILs with different cations or anions were employed in the solubilization and extraction of curcumin. It seems that the hydrophobic chain of ILs plays a key role. Superior solubilization and extraction capacity were achieved with surface-active ionic liquids (SAILs), which contain long alkyl chain and a charged hydrophilic head group, resulting in their ability of aggregation and micelle formation. To put an insight into the ILs-curcumin interaction and the solubilization mechanism, UV-vis spectroscopic studies, density functional theory (DFT) calculation, and H-1 NMR studies were carried out. At first, curcumin undergoes diketone-enol tautomerism with the binding of ILs monomer. Then, SAILs begin to aggregate and form micelle with the increased concentration, meanwhile, the solubility of curcumin is remarkably enhanced. The solubilized curcumin is located in the palisade of micelle in which a hydrophobic environment is provided. (C) 2020 Published by Elsevier B.V.
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