期刊
JOURNAL OF MEDICINAL FOOD
卷 23, 期 8, 页码 811-817出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2019.4552
关键词
Achyranthes japonica Nakai; knee joint; monoiodoacetate; osteoarthritis
资金
- Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) through the High Valueadded Food Technology Development Program - Ministry of Agriculture, Food and Rural Affairs (MAFRA) [117054-3]
We demonstrated the effect of a mixture containing fermentedAchyranthes japonicaNakai (FS) in the context of a monosodium iodoacetate (MIA)-induced osteoarthritis animal model. The mineralization, anabolic and catabolic factors, and the amount of cytokines within the articular cartilage of rats were measured after administration of MIA. We found that dietary supplementation with methylsulfonylmethane (positive control) and FS (FS 100 mg/kg body weight [b.w.] and FS 300 mg/kg b.w.) effectively suppressed pathological changes in the knee joint and inhibited changes in the architectural and mineralization parameters. In addition, prostaglandin E2 (PGE2) and proinflammatory cytokines in the serum and catabolic factors, including matrix metalloproteinase (MMP)-3 and MMP-7 in articular cartilage, were decreased by dietary supplementation with FS in MIA-induced osteoarthritis. Based on these findings, we suggest that FS can be used for the development of potential therapies for osteoarthritis.
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