期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 63, 期 15, 页码 8584-8607出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.0c00988
关键词
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The C-C chemokine receptor 4 (CCR4) is broadly expressed on regulatory T cells (T-reg) as well as other circulating and tissue-resident T cells. T-reg can be recruited to the tumor microenvironment (TME) through the C-C chemokines CCL17 and CCL22. T-reg accumulation in the TME has been shown to dampen the antitumor immune response and is thought to be an important driver in tumor immune evasion. Preclinical and clinical data suggest that reducing the T-reg population in the TME can potentiate the antitumor immune response of checkpoint inhibitors. We have developed small-molecule antagonists of CCR4, featuring a novel piperidinyl-azetidine motif; that inhibit the recruitment of T-reg into the TME and elicit antitumor responses as a single agent or in combination with an immune checkpoint blockade. The discovery of these potent, selective, and orally bioavailable CCR4 antagonists, and their activity in in vitro and in vivo models, is described herein.
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