Analysis of the application value of serum antibody detection for staging of COVID-19 infection

Coronavirus disease 2019 (COVID-19) has now spread all over the world. The National Health Commission of the People's Republic of China reported 78 439 cured and discharged cases, 4634 deaths, 83 462 confirmed cases and 760 818 close contacts as of 25 June 2020. Joint detection of nucleic acids and antibodies has become an important laboratory diagnostic for COVID-19 patients. Disease progression and infection stage can be established based on the biological characteristics of these tests. However, there have been few studies of the different infection stages of COVID-19. We conducted a retrospective analysis to explore the clinical characteristics of COVID-19 patients at different infection stages and to characterize the characteristics of specific serum antibodies at each stage. These pieces of data will provide a theoretical basis for clinical diagnosis and treatment.

Automated summary

COVID-19 has spread worldwide, with a significant number of cases reported by the National Health Commission of China as of June 25, 2020. Joint detection of nucleic acids and antibodies has become a key diagnostic method, yet there is limited research on the different infection stages. A retrospective analysis exploring the clinical characteristics of COVID-19 patients at different stages could provide crucial theoretical basis for clinical diagnosis and treatment.