期刊
BMC CANCER
卷 15, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12885-015-1669-z
关键词
Nasopharyngeal neoplasms; Intensity-modulated radiotherapy; Elective neck irradiation; Level Ib
类别
资金
- Health & Medical Collaborative Innovation Project of Guangzhou City, China [201400000001]
- National Science & Technology Pillar Program during the Twelfth Five-year Plan Period [2014BAI09B10]
- Planned Science and Technology Project of Guangdong Province [2013B021800175]
- Key Laboratory Construction Project of Guangzhou City, China [121800085]
- Sun Yat-Sen University Clinical Research 5010 Program [2012011]
Background: To assess the feasibility of elective neck irradiation to level Ib in nasopharyngeal carcinoma (NPC) using intensity-modulated radiation therapy (IMRT). Methods: We retrospectively analyzed 1438 patients with newly-diagnosed, non-metastatic and biopsy-proven NPC treated with IMRT. Results: Greatest dimension of level IIa LNs (DLN-IIa) >= 20 mm and/or level IIa LNs with extracapsular spread (ES), oropharynx involvement and positive bilateral cervical lymph nodes (CLNs) were independently significantly associated with metastasis to level Ib LN at diagnosis. No recurrence at level Ib was observed in the 904 patients without these characteristics (median follow-up, 38.7 months; range, 1.3-57.8 months), these patients were classified as low risk. Level Ib irradiation was not an independent risk factor for locoregional failure-free survival, distant failure-free survival, failure-free survival or overall survival in low risk patients. The frequency of grade >= 2 subjective xerostomia at 12 months after radiotherapy was not significantly different between low risk patients who received level Ib-sparing, unilateral level Ib-covering or bilateral level Ib-covering IMRT. Conclusion: Level Ib-sparing IMRT should be safe and feasible for patients without a DLN-IIa >= 20 mm and/or level IIa LNs with ES, positive bilateral CLNs or oropharynx involvement at diagnosis. Further investigations based on specific criteria for dose constraints for the submandibular glands are warranted to confirm the benefit of elective level Ib irradiation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据