期刊
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
卷 63, 期 -, 页码 236-245出版社
JOURNAL MATER SCI TECHNOL
DOI: 10.1016/j.jmst.2020.06.001
关键词
Carboxymethyl chitosan; Injectable melatonin-containing hydrogel; Wound healing; Antiinflammatory; Angiogenesis; Collagen deposition
资金
- National Natural Science Foundation of China [U1608255]
- Key R&D Projects of Science and Technology Department in Jiangxi Province [20192BBGL70032]
- PLA fundation of China [AWS15J004-2-1]
- Project of Science and Technology of Jiangxi [20171BAB216038]
- Open Project of State Key Laboratory of Supramolecular Structure and Materials
The melatonin-loaded hydrogel promotes granulation tissue formation, accelerates wound healing, and reduces inflammation levels.
Carboxymethyl chitosan (CMCS)-based hydrogels have antibacterial activity, and have shown the abilities of preventing wound infection, promoting cell proliferation, accelerating collagen deposition, and stimulating hyaluronic acid formation during wound healing. As a hormone produced by the pineal gland in humans and animals, melatonin promotes skin wound healing by regulating the release of inflammatory mediators and accelerating the proliferation and migration of cells, angiogenesis, and collagen deposition. However, the combined effects of CMCS and melatonin on wound healing remain unclear. Injectable CMCS-based hydrogels containing melatonin were prepared, and their healing effects were evaluated using a full-thickness cutaneous wound model in rats. Compared with the control and the hydrogel with no melatonin groups, the melatonin-loaded hydrogel significantly increased the percentage of wound closure, promoted the proliferation of granulation tissue and re-epithelialization, and accelerated collagen deposition. Additionally, the melatonin-loaded hydrogel promoted angiogenesis and vascular endothelial growth factor receptor protein expression and increased the expression of cyclooxygenase-2 and inducible nitric oxide synthase. The melatonin-loaded hydrogel also markedly increased the expression of collagen III, a-smooth muscle actin, and transforming growth factor-(31 proteins and reduced collagen I expression. These results suggest that the melatonin-loaded hydrogel promoted granulation tissue formation and accelerated wound healing by reducing inflammation and promoting angiogenesis and collagen deposition. (C) 2020 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
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