期刊
JOURNAL OF MASS SPECTROMETRY
卷 55, 期 10, 页码 -出版社
WILEY
DOI: 10.1002/jms.4617
关键词
LC-ESI-MS; MS; N-iodosuccinimide; phosphonic acid hydrolysis products; structural elucidation; V-nerve agents
V-nerve agents present information-poor spectra, both in GC-EI-MS and LC-ESI-MS/MS, with dominant fragments/product ions corresponding to the amine-containing residue. Hence, derivatives/isomers with the same amine residue exhibit similar mass spectral patterns, leading to ambiguity in the phosphonate structure. We present a simple approach for their structural elucidation based on two complementary experiments: ESI-MS/MS of the original compound, which provides information about the amine moiety, and ESI-MS/MS of the phosphonic acid hydrolysis products generated byN-iodosuccinimide, which provides ions' characteristic of the phosphonate structure. This approach enables the structural elucidation of the original V-agents with a higher degree of certainty.
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