期刊
CLINICAL GENETICS
卷 91, 期 2, 页码 254-264出版社
WILEY
DOI: 10.1111/cge.12897
关键词
DNA methylation; endometriosis; GWAS; histone post-translational modifications; miRNA
Endometriosis is a gynecologic disease affecting up to 10% of the women and a major cause of pain and infertility. It is characterized by the implantation of functional endometrial tissue at ectopic positions generally within the peritoneum. This complex disease has an important genetic component with a heritability estimated at around 50%. This review aims at providing recent insights into the genetic bases of endometriosis, and presents a detailed overview of evidence of epigenetic alterations specific to this disease. In the future, these alterations may constitute therapeutic targets for pharmacological compounds able to modify the epigenetic code.
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