期刊
JOURNAL OF INVESTIGATIVE DERMATOLOGY
卷 141, 期 1, 页码 164-+出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jid.2020.04.030
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资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [18K09473, 19H03812, 19K22649, 19K19494]
Dectin-1 accelerates wound healing by inducing early-phase neutrophil accumulation, while Dectin-2 is involved in prolonged neutrophilic responses and neutrophil extracellular trap formation, leading to delayed wound healing.
C-type lectin receptors recognize microbial polysaccharides. The C-type lectin receptors such as dendritic cell-associated C-type lectin (Dectin)-1 and Dectin-2, which are triggered by beta-glucan and alpha-mannan, respectively, contribute to upregulation of the inflammatory response. Recently, we demonstrated that activation of the Dectin-2 signal delayed wound healing; in previous studies, triggering the Dectin-1 signal promoted this response. However, the precise roles of these C-type lectin receptors in skin wound healing remain unclear. This study was conducted to determine the roles of Dectin-1 and Dectin-2 in skin wound healing, with a particular focus on the kinetics of neutrophilic inflammatory response. Full-thickness wounds were created on the backs of C57BL/6 mice, and the effects of Dectin-1 or Dectin-2 deficiency and those of beta-glucan or alpha-mannan administration were examined. We also analyzed wound closure, histological findings, and neutrophilic inflammatory response, including neutrophil extracellular trap formation at the wound sites. We found that Dectin-1 contributed to the acceleration of wound healing by inducing early-phase neutrophil accumulation, whereas Dectin-2 was involved in prolonged neutrophilic responses and neutrophil extracellular trap formation, leading to delayed wound healing. Dectin-2 deficiency also improved collagen deposition and TGF-beta 1 expression. These results suggest that Dectin-1 and Dectin-2 have different roles in wound healing through their different effects on the neutrophilic response.
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