期刊
JOURNAL OF INFECTIOUS DISEASES
卷 222, 期 5, 页码 746-754出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiaa363
关键词
SARS-CoV-2; cytokine; chemokine; disease severity
资金
- National Natural Science Foundation of China [81601732, 31570926, 81871666, 31700035]
- Natural Science Foundation of Jiangsu Province [BK20191489]
- Key Research and Development Project of Jiangsu Province [BE2019761, BE2017748]
- Jiangsu provincial Medical Youth Talent [QNRC2016537, JKRC2016018]
- The Six One Project of Jiangsu Province [LGY2017084]
Coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We investigated the serum cytokine and chemokine levels in asymptomatic, mild, moderate, severe, and convalescent SARS-CoV-2-infected cases. Proinflammatory cytokine and chemokine production induced by SARS-CoV-2 were observed not only in symptomatic patients but also in asymptomatic cases, and returned to normal after recovery. IL-6, IL-7, IL-10, IL-18, G-CSF, M-CSF, MCP-1, MCP-3, IP-10, MIG, and MIP-1 alpha were found to be associated with the severity of COVID-19. Moreover, a set of cytokine and chemokine profiles were significantly higher in SARS-CoV-2-infected male than female patients. The serum levels of MCP-1, G-CSF, and VEGF were weakly and positively correlated with viral titers. We suggest that combinatorial analysis of serum cytokines and chemokines with clinical classification may contribute to evaluation of the severity of COVID-19 and optimize the therapeutic strategies.
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