期刊
JOURNAL OF INFECTIOUS DISEASES
卷 222, 期 6, 页码 894-898出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiaa349
关键词
COVID-19; fractalkine; endothelial cell adhesion molecules; D-dimer; coagulopathy
资金
- Key Research and Development Program of Hunan Province [2020SK3011]
In a retrospective study of 39 COVID-19 patients and 32 control participants in China, we collected clinical data and examined the expression of endothelial cell adhesion molecules by enzyme-linked immunosorbent assays. Serum levels of fractalkine, vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and vascular adhesion protein-1 (VAP-1) were elevated in patients with mild disease, dramatically elevated in severe cases, and decreased in the convalescence phase. We conclude the increased expression of endothelial cell adhesion molecules is related to COVID-19 disease severity and may contribute to coagulation dysfunction.
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