期刊
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
卷 68, 期 11, 页码 747-762出版社
SAGE PUBLICATIONS LTD
DOI: 10.1369/0022155420937371
关键词
extracellular matrix; glycosaminoglycan; proteoglycan
类别
资金
- Intramural Research Program of the NIH, NIDCR, Molecular Biology of Bones and Teeth Section [Z01DE000379-35]
- Research Foundation-Flanders (FWO) [12X8520N]
- European Research Council [Genomia-ERC-COG-2017-771945]
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [ZIADE000379] Funding Source: NIH RePORTER
Small leucine rich proteoglycans (SLRPs), including Biglycan, have key roles in many organ and tissue systems. The goal of this article is to review the function of Biglycan and other related SLRPs in mineralizing tissues of the skeleton. The review is divided into sections that include Biglycan's role in structural biology, signaling, craniofacial and long bone homeostasis, remodeled skeletal tissues, and in human genetics. While many cell types in the skeleton are now known to be affected by Biglycan, there are still unanswered questions about its mechanism of action(s).
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