期刊
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
卷 68, 期 12, 页码 841-862出版社
SAGE PUBLICATIONS LTD
DOI: 10.1369/0022155420933709
关键词
biomarker; cancer; extracellular matrix; glycosaminoglycan; glypican; heparan sulfate proteoglycan; immunostaining
类别
资金
- Intramural Research Program of National Institutes of Health, National Cancer Institute [Z01 BC010891, ZIA BC010891]
- NATIONAL CANCER INSTITUTE [ZIABC010891] Funding Source: NIH RePORTER
Glypicans are a family of heparan sulfate proteoglycans that are attached to the cell membrane via a glycosylphosphatidylinositol anchor. Glypicans interact with multiple ligands, including morphogens, growth factors, chemokines, ligands, receptors, and components of the extracellular matrix through their heparan sulfate chains and core protein. Therefore, glypicans can function as coreceptors to regulate cell proliferation, cell motility, and morphogenesis. In addition, some glypicans are abnormally expressed in cancers, possibly involved in tumorigenesis, and have the potential to be cancer-specific biomarkers. Here, we provide a brief review focusing on the expression of glypicans in various cancers and their potential to be targets for cancer therapy.
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