期刊
JOURNAL OF HEMATOLOGY & ONCOLOGY
卷 13, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13045-020-00932-z
关键词
Tissue factor; Protease-activated receptors; Receptor tyrosine kinases; Integrins; Metastasis; Angiogenesis
资金
- National Institutes of Health (NIH) [F32CA216996]
- NIH [R01NS102669, R01NS117104]
- Northwestern University SPORE in Brain Cancer [P50CA221747]
- Lou and Jean Malnati Brain Tumor Institute
Tissue factor (TF) is the primary initiator of the coagulation cascade, though its effects extend well beyond hemostasis. When TF binds to Factor VII, the resulting TF:FVIIa complex can proteolytically cleave transmembrane G protein-coupled protease-activated receptors (PARs). In addition to activating PARs, TF:FVIIa complex can also activate receptor tyrosine kinases (RTKs) and integrins. These signaling pathways are utilized by tumors to increase cell proliferation, angiogenesis, metastasis, and cancer stem-like cell maintenance. Herein, we review in detail the regulation of TF expression, mechanisms of TF signaling, their pathological consequences, and how it is being targeted in experimental cancer therapeutics.
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