4.4 Article

A novel antiviral formulation inhibits a range of enveloped viruses

期刊

JOURNAL OF GENERAL VIROLOGY
卷 101, 期 10, 页码 1090-1102

出版社

MICROBIOLOGY SOC
DOI: 10.1099/jgv.0.001472

关键词

antiviral; enveloped virus; Zika; measles; herpes simplex; pseudovirus; coronavirus

资金

  1. Thomas O'Hanlon scholarship for veterinary medicine, University College Dublin, Ireland
  2. Westgate Biomedical Ltd
  3. UK MRC New Investigator Research Grant [MR/P021735/1]
  4. BBSRC [BBS/E/I/00007038, BBS/E/I/00007039, BBS/E/I/00007034] Funding Source: UKRI
  5. MRC [MR/N023781/1] Funding Source: UKRI

向作者/读者索取更多资源

Some free fatty acids derived from milk and vegetable oils are known to have potent antiviral and antibacterial properties. However, therapeutic applications of short- to medium-chain fatty acids are limited by physical characteristics such as immiscibility in aqueous solutions. We evaluated a novel proprietary formulation based on an emulsion of short-chain caprylic acid. ViroSAL, for its ability to inhibit a range of viral infections in vitro and in vivo. In vitro, ViroSAL inhibited the enveloped viruses Epstein-Barr, measles, herpes simplex, Zika and orf parapoxvirus, together with Ebola, Lassa, vesicular stomatitis and severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) pseudoviruses, in a concentration- and time-dependent manner. Evaluation of the components of ViroSAL revealed that caprylic acid was the main antiviral component; however, the ViroSAL formulation significantly inhibited viral entry compared with caprylic acid alone. In vivo, ViroSAL significantly inhibited Zika and Semliki Forest virus replication in mice following the inoculation of these viruses into mosquito bite sites. In agreement with studies investigating other free fatty acids, ViroSAL had no effect on norovirus, a non-enveloped virus, indicating that its mechanism of action may be surfactant disruption of the viral envelope. We have identified a novel antiviral formulation that is of great interest for the prevention and/or treatment of a broad range of enveloped viruses, particularly those of the skin and mucosal surfaces.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据