期刊
CLINICAL ENDOCRINOLOGY
卷 85, 期 4, 页码 636-644出版社
WILEY-BLACKWELL
DOI: 10.1111/cen.13045
关键词
-
资金
- UK Medical Research Council [26659]
- Imperial College Healthcare Charity [7006/R21U]
- Guarantors of Brain
- Wellcome-GSK Imperial Translational Training Fellowship
- Wellcome Trust
- National Institute for Health Research (NIHR)
- National Institute for Health Research (NIHR) [NIHR-RP-011-048]
- UK Medical Research Council
- MRC [MR/K023926/1] Funding Source: UKRI
- Academy of Medical Sciences (AMS) [AMS-SGCL13-Gorgoraptis] Funding Source: researchfish
- Medical Research Council [MR/K023926/1] Funding Source: researchfish
- National Institute for Health Research [CL-2013-21-010, NIHR-RP-011-048] Funding Source: researchfish
Objectives Traumatic brain injury (TBI) is a major cause of long-term disability with variable recovery. Preclinical studies suggest that vitamin D status influences the recovery after TBI. However, there is no published clinical data on links between vitamin D status and TBI outcomes. The aim was to determine the (i) prevalence of vitamin D deficiency/insufficiency, and associations of vitamin D status with (ii) demographic factors and TBI severity, and with (iii) cognitive function, symptoms and quality of life, in adults after TBI. Design Retrospective audit of patients seen between July 2009 and March 2015. Serum vitamin D (25-hydroxy-cholecalciferol) was categorized as deficient (<40 nmol/l), insufficient (4070 nmol/l) or replete (>70 nmol/l). Patients A total of 353 adults seen in tertiary hospital clinic (75.4% lighter skinned, 74.8% male, age median 35.1 year, range 26.6-48.3 year), 0.3-56.5 months after TBI (74.5% moderate-severe). Measurements Serum vitamin D concentrations; Adden-brooke's Cognitive Examination (ACE-R), Beck Depression Inventory-II (BDI-II), SF-36 Quality of Life, Pittsburgh Sleep Quality Index. Results In total, 46.5% of patients after TBI had vitamin D deficiency and 80.2% insufficiency/deficiency. Patients with vitamin D deficiency had lower ACE-R scores than those of vitamin D replete (mean effect size +/- SEM 4.5 +/- 2.1, P = 0.034), and higher BDI-II scores than those of vitamin D insufficient (4.5 +/- 1.6, P = 0.003), correcting for age, gender, time since TBI and TBI severity. There was no association between vitamin D status and markers of TBI severity, sleep or quality of life. Conclusion Vitamin D deficiency is common in patients after TBI and associated with impaired cognitive function and more severe depressive symptoms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据