期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 217, 期 10, 页码 -出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20200483
关键词
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资金
- National Institutes of Health [R35CA-210105]
- NIH/NCI Cancer Center Support grant [P30CA013696]
In response to T cell-dependent antigens, mature B cells are stimulated to form germinal centers (GCs), the sites of B cell affinity maturation and the cell of origin (COO) of most B cell lymphomas. To explore the dynamics of GC B cell development beyond the known dark zone and light zone compartments, we performed single-cell (sc) transcriptomic analysis on human GC B cells and identified multiple functionally linked subpopulations, including the distinct precursors of memory B cells and plasma cells. The gene expression signatures associated with these GC subpopulations were effective in providing a sc-COO for similar to 80% of diffuse large B cell lymphomas (DLBCLs) and identified novel prognostic subgroups of DLBCL.
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