期刊
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
卷 57, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jddst.2020.101689
关键词
Asparaginase; Nanobiocomposite; Brain cancer cell lines; Characterization; Anticancer activity
L-Asparaginase acts as a therapeutic agent for cancer. The free L-asparaginase has innumerable side effects on the human body. The source of L-asparaginase also plays a major role in the effectiveness of the therapeutic agent. In the present research work, L-asparaginase was produced from a fungal strain Aspergillus terreus. The free enzyme was then immobilised onto a nanobiocomposite consisting of Gelatin and beta-cyclodextrin. Both Gelatin and beta-Cyclodextrin are biodegradable and are non-toxic. The nanobiocomposite was subjected to characterization studies like the UV-Vis spectra analysis which confirms the presence of the nanobiocomposite. The FTIR analysis of the nanobiocomposite confirmed the functional group present in the nanobiocomposite. The NMR analysis confirmed the chemical shift of the nanobiocomposite. The AFM analysis was used to study surface morphology of the nanobiocomposite. The anticancer activity for the brain cancer cell line and cervical cancer cell line was found as 42.13% at 500 mu g/ml and 48.60% at 62.5 mu g/ml respectively.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据