期刊
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
卷 58, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jddst.2020.101810
关键词
Microspheres; Mesoporous bioactive glass; Ropivacaine; Sciatic nerve block
资金
- National Natural Science Foundation of China [51273171]
- Wuxi City Commission of Health [MS201709]
Local anesthetics are mainly used for regional anesthesia and analgesia. However, the duration of action is limited in clinical applications. In the present study, we developed a ropivacaine (RPC)-loaded mesoporous bioactive glass (MBG) microspheres for an extended analgesic duration. First, MBG microspheres were prepared using a template synthesis method. RPC was then loaded into the MBG microspheres through immersion, fol-lowed by centrifugation and drying. Finally, the RPC-loaded MBG microspheres were coated with a polylactic acid-b-polyethylene glycol (PLA-PEG) copolymer to obtain RPC-MBG composite microspheres (RPC micro-spheres). The particle size and zeta potential of the RPC microspheres were 192.3 +/- 9.6 nm and -35.6 +/- 3.5 mV, with entrapment efficiency (EE) of 88.2 +/- 3.2% and low cytotoxicity. In vitro, the release profile of RPC microspheres exhibited a biphasic pattern: an initial release burst within the first hour, followed by subsequent slower and sustained release. After performing a single-shot sciatic nerve block, a fast the an-esthetic effect and prolonged analgesic effect were achieved. Given the low cytotoxicity and sustained release, the RPC microspheres developed in this study could be used as a long-acting local anesthetic.
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