Secukinumab retreatment associated psoriasis flare with pustules

This case report describes a patient with plaque psoriasis and psoriatic arthritis who experienced IL-17A blocking antibody secukinumab treatment-interruption followed by re-treatment. The patient showed heterogeneous responses; significant improvement at initial introduction of secukinumab with rapid deterioration after discontinuation, followed by worsening symptoms and pustular eruption with reintroduction, and skin clearance after dose escalation.

Automated summary

This case report describes the varied response of a patient with plaque psoriasis and psoriatic arthritis to treatment-interruption and re-treatment with the IL-17A blocking antibody secukinumab.