期刊
JOURNAL OF CONTROLLED RELEASE
卷 324, 期 -, 页码 598-609出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2020.06.003
关键词
Alternative magnetic field; Amorphous iron nanoparticles; Antibacterial; Wound disinfection; Chemodynamic
资金
- National Natural Science Foundation of China [51971116, 81771981, 81671829]
Utilizing the iron-carrying nanomaterials for Fenton chemistry mediation to catalyze decomposition of hydrogen peroxide and generate toxic hydroxyl radical (center dot OH) has drawn much attention in antimicrobial therapy field. However, these nanomaterials are usually with unsatisfactory catalytic efficacy and lack of the capacity to modulate the catalytic activity, which may give the bacteria opportunity in developing resistance against the antibacterial treatment. Herein, we systematically investigated the influence of alternating magnetic field (AMF) on the catalytic activity and antibacterial efficiency of the amorphous iron nanoparticles (AIronNPs). With rapidly ionized and the AMF augmented chemodynamic effect, the AIronNPs can convert low concentration of H2O2 into more center dot OH, the possible mechanism might be attributed to the accelerated ferrous iron ions releasing with AMF exposure. As a proof of concept, the AIronNPs and AMF synergetic antibacterial system have shown excellent broad-spectrum antimicrobial properties, 91.89% antibacterial efficiency is shown toward Escherichia coli and 92.65% toward Staphylococcus aureus. It also facilitated the formation of granulation tissue and accelerated wound healing on in vivo infected model, whereas AIronNPs alone have limited effect. We believe this work will broaden the thoughts for spatiotemporally manipulating the catalytic activity of nanomaterials and advance the development of magnetic nano-antibiotics in the antibacterial field.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据