期刊
JOURNAL OF CONTROLLED RELEASE
卷 322, 期 -, 页码 401-415出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2020.03.036
关键词
Multifunctional NPs; Anticancer therapy; Rotating magnetic field; Magneto-cell-lysis; Magneto-cell-apoptosis
资金
- National Natural Science Foundation of China [81603037]
- Natural Science Foundation of Hubei Province [2019CFB490]
Multifunctional magnetic nanoparticles (MNPs) were widely used for ablation of cancer cells because of their potential on physical treatment. Herein, we developed the cell targeting destructive multifunctional polymeric nanoparticles (named as HA-Olb-PPMNPs) based on PEI-PLGA co-loaded with the anticancer drug Olaparib (Olb) and superparamagnetic iron oxide nanoparticles (Fe3O4 NPs), and further coated with a low molecular weight hyaluronic acid (HA) on its surface. Due to the high affinity between HA and CD44-receptor on cell surface of triple negative breast cancer (TNBC), an active targeting can be achieved. Under a rotating magnetic field (RMF), HA-Olb-PPMNPs produced a physical transfer of mechanical force by incomplete rotation. This mechanical force could cause the two strikes effect on the cells, in which First-strike was to damage the cell membrane structure (magneto-cell-lysis), another Second-strike could activate the lysosome-mitochondrial pathway by injuring lysosomes to induce cell apoptosis (magneto-cell-apoptosis). Therefore, the mechanical force and Olb exert dual anti-tumor effect to achieve synergistic therapeutic in the presence of RMF. This study proposes a novel multi-therapeutic concept for TNBC, as well as provided evidences of new anti-tumor therapeutic effects induced by the magnetic nanoparticles drug system.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据