期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 529, 期 4, 页码 885-904出版社
WILEY
DOI: 10.1002/cne.24986
关键词
dorsal premotor cortex; medial prefrontal cortex; medial temporal; non-human primate; RRID; AB_2340397; RRID; SCR_002526; RRID; AB_221558; RRID; AB_221561; RRID; AB_2313606; RRID; AB_2336382; RRID; AB_2336819; RRID; AB_2536192; RRID; AB_2536196; RRID; SCR_000432; RRID; SCR_001622; RRID; SCR_002465; tract-tracing
资金
- National Institute of Health (NIH), National Institute of Mental Health (NIMH) [K99/R00MH101234, R01/MH116008]
The study revealed that connections from the entorhinal and dorsal premotor cortex are segregated in specific subregions of the ACC, while amygdalar connections are more evenly distributed. In the ventral ACC, entorhinal and amygdalar connections strongly overlap, particularly in A25. Meanwhile, in the dorsal ACC, outputs to PMC and amygdala are densely interconnected in deep layers.
The anterior cingulate cortex (ACC) is important for decision-making as it integrates motor plans with affective and contextual limbic information. Disruptions in these networks have been observed in depression, bipolar disorder, and post-traumatic stress disorder. Yet, overlap of limbic and motor connections within subdivisions of the ACC is not well understood. Hence, we administered a combination of retrograde and anterograde tracers into structures important for contextual memories (entorhinal cortex), affective processing (amygdala), and motor planning (dorsal premotor cortex) to assess overlap of labeled projection neurons from (outputs) and axon terminals to (inputs) the ACC of adult rhesus monkeys (Macaca mulatta). Our data show that entorhinal and dorsal premotor cortical (dPMC) connections are segregated across ventral (A25, A24a) and dorsal (A24b,c) subregions of the ACC, while amygdalar connections are more evenly distributed across subregions. Among all areas, the rostral ACC (A32) had the lowest relative density of connections with all three regions. In the ventral ACC, entorhinal and amygdalar connections strongly overlap across all layers, especially in A25. In the dorsal ACC, outputs to dPMC and the amygdala strongly overlap in deep layers. However, dPMC input to the dorsal ACC was densest in deep layers, while amygdalar inputs predominantly localized in upper layers. These connection patterns are consistent with diverse roles of the dorsal ACC in motor evaluation and the ventral ACC in affective and contextual memory. Further, distinct laminar circuits suggest unique interactions within specific ACC compartments that are likely important for the temporal integration of motor and limbic information during flexible goal-directed behavior.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据