期刊
CLINICAL CARDIOLOGY
卷 39, 期 10, 页码 565-569出版社
WILEY
DOI: 10.1002/clc.22565
关键词
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资金
- Bayer HealthCare Pharmaceuticals
- Bayer Pharma AG
- Janssen Scientific Affairs
- Boehringer Ingelheim Pharmaceuticals Inc.
- Daiichi Sankyo Company
- Portola Pharmaceuticals
- Janssen Research & Development, LLC
- 3M Medica
- MEDA Pharma
- AstraZeneca
- Bayer HealthCare
- Biosense Webster
- Boehringer Ingelheim
- Daiichi Sankyo
- German Cardiac Society
- Medtronic
- Merck
- MSD
- Otsuka Pharma
- Pfizer/Bristol-Myers Squibb
- Sanofi
- Servier
- Siemens
- Takeda
- British Heart Foundation [FS/13/43/30324] Funding Source: researchfish
Background: The efficacy, safety, and ease of use of rivaroxaban may reduce anticoagulation-treatment burden and improve nonvalvular atrial fibrillation (NVAF) patient satisfaction compared with vitamin K antagonists (VKAs). Hypothesis: Transitioning from a VKA to rivaroxaban improves treatment satisfaction in routine practice. Methods: Xarelto for Prevention of Stroke in Patients With Atrial Fibrillation (XANTUS) is a prospective, noninterventional study in patients with NVAF prescribed rivaroxaban for prevention of stroke in routine practice. Patients receiving a VKA 4 weeks prior to the initial XANTUS study visit and switched to rivaroxaban were asked to complete the Anti-Clot Treatment Scale (ACTS). Changes from the initial visit to the first follow-up visit at similar to 3 months (corresponding to a comparison of rivaroxaban vs prior VKA) for ACTS burden and benefit scores were calculated using and reported as least squared mean differences (LSMDs) with 95% confidence intervals (CIs). Results: The study included 1291 NVAF patients with prior VKA treatment. The mean baseline ACTS burden and benefit scores were 50.51+/-8.42 and 10.30+/-2.70, respectively. After similar to 3 months of rivaroxaban treatment, LSMDs were 4.38 points (95% CI: 2.53-6.22, P < 0.0001) for the burden and 1.01 points (95% CI: 0.27-1.75, P = 0.0075) for the benefit score. Fifty-four percent and 48% of patients reported experiencing at least a minimally important clinical difference in burden and benefit scores, respectively. Conclusions: Within this XANTUS cohort, switching from a VKA to rivaroxaban yielded statistically and clinically significant improvements in ACT burden and benefit scores.
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