期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 41, 期 4, 页码 723-730出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X20938137
关键词
Ischemia; neuroprotection; rhesus; salvinorin A; stroke
资金
- National Key Research and Development Program of China [2016YFC1301502]
- National Natural Science Foundation of China [81620108011, 81871022, 81771260]
- Mission Talent Project of Beijing Municipal Administration of Hospitals [SML20150802]
- China Research Engagement Funding from the University of Pennsylvania [CREF-030]
Intranasal administration of SA reduced infarct volume, occupancy effect, and diffusion limitation in the lesion, leading to significantly improved neurological outcomes in a rhesus monkey ischemic stroke model over a 28-day observation period.
Salvinorin A (SA) exerts neuroprotection and improves neurological outcomes in ischemic stroke models in rodents. In this study, we investigated whether intranasal SA administration could improve neurological outcomes in a monkey ischemic stroke model. The stroke model was induced in adult male rhesus monkeys by occluding the middle cerebral artery M2 segment with an autologous blood clot. Eight adult rhesus monkeys were randomly administered SA or 10% dimethyl sulfoxide as control 20 min after ischemia. Magnetic resonance imaging was used to confirm the ischemia and extent of injury. Neurological function was evaluated using the Non-Human Primate Stroke Scale (NHPSS) over a 28-day observation period. SA significantly reduced infarct volume (3.9 +/- 0.7 cm(3)vs. 7.2 +/- 1.0 cm(3);P = 0.002), occupying effect (0.3 +/- 0.2% vs. 1.4 +/- 0.3%;P = 0.002), and diffusion limitation in the lesion (-28.2 +/- 11.0% vs. -51.5 +/- 7.1%;P = 0.012) when compared to the control group. SA significantly reduced the NHPSS scores to almost normal in a 28-day observation period as compared to the control group (P = 0.005). Intranasal SA reduces infarct volume and improves neurological outcomes in a rhesus monkey ischemic stroke model using autologous blood clot.
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