期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 236, 期 2, 页码 1105-1115出版社
WILEY
DOI: 10.1002/jcp.29919
关键词
autonomic nervous system; exercise; metabolomics; myocardial infarction; ovariectomy
资金
- Fundacao de Amparo a Pesquisa do Estado de SAo Paulo (FAPESP) [2013/14788-9]
- CoordenacAo de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) [001]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq-BPQ) [309684/2016-1]
The study evaluated the impact of aerobic training on autonomic, cardiometabolic, ubiquitin-proteasome activity, and inflammatory changes in ovariectomized rats with myocardial infarction. Aerobic training improved physical capacity, increased interleukin-10, and decreased pro-inflammatory cytokines. Metabolomic analysis revealed distinct metabolic profiles among different groups, with aerobic training group showing prevention of certain metabolic responses.
This study aimed to evaluate the impact of aerobic training (AT) on autonomic, cardiometabolic, ubiquitin-proteasome activity, and inflammatory changes evoked by myocardial infarction (MI) in ovariectomized rats. Female Wistar rats were ovariectomized and divided into four groups: sedentary + sham (SS), sedentary + MI (SI), AT + sham surgery (TS), AT + MI (TI). AT was performed on a treadmill for 8 weeks before MI. Infarcted rats previously subjected to AT presented improved physical capacity, increased interleukin-10, and decreased pro-inflammatory cytokines. Metabolomic analysis identified and quantified 62 metabolites, 9 were considered significant by the Vip Score. SS, SI, and TS groups presented distinct metabolic profiles; however, TI could not be distinguished from the SS group. MI dramatically increased levels of dimethylamine, and AT prevented this response. Our findings suggest that AT may be useful in preventing the negative changes in functional, inflammatory, and metabolic parameters related to MI in ovariectomized rats.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据