期刊
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
卷 76, 期 3, 页码 255-266出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/FJC.0000000000000869
关键词
TLR; sex difference; blood pressure; hypertension
资金
- National Institutes of Health (NIH) [PO1 HL-13604]
- Fundacao de Amparo a Pesquisa do Estado de Mato Grosso (FAPEMAT) [0324552/2018]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [305823/2015-9]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [88881.190484/2018-01]
- Fundacao de Amparo a Pesquisa do Estado de Goias (FAPEG)-CAPES [201710267001159]
Toll-like receptors (TLRs) play an important role in the innate immune system, and recently, they have been shown to be involved in the regulation of blood pressure. The incidence of hypertension is higher in men, and it increases in postmenopausal women. In fact, premenopausal women are protected from cardiovascular disease compared with age-matched men, and it is well established that this protective effect is lost with menopause. However, the molecular mechanisms underlying this protection in women are unknown. Whether or not it could be related to differential activation of the innate immune system remains to be elucidated. This review focuses on (1) the differences between men and women in TLR activation and (2) whether TLR activation may influence the regulation of blood pressure in a sex-dependent manner.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据